反応 #461133
ord-1e13144963b84e68964e7c115b7dd202
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1温度is refluxed for 24 hours
- 2その他generated is removed by means of an aspirator
- 3その他The organic and aqueous layers are then separated
- 4抽出the aqueous layer extracted with ethylacetate
- 5乾燥The combined organic extracts are dried (magnesium sulfate)
- 6その他evaporated
実験手順
A mixture of 4-chlorobutyronitrile, (0.05 mol) sodium azide (0.20 mol) and anhydrous aluminum chloride (0.05 mol) in 100 ml of dry tetrahydrofuran is refluxed for 24 hours. After cooling to ambient temperature the reaction is acidified with 75 ml of 15% hydrochloric acid while the hydrazoic acid generated is removed by means of an aspirator. The organic and aqueous layers are then separated and the aqueous layer extracted with ethylacetate. The combined organic extracts are dried (magnesium sulfate) and evaporated to give 5-(3-chloropropyl)tetrazole which is used directly in the next step.