反応 #46053

反応方程式

5-amino-1H-benzotriazole

ninhydrin

acetic anhydride

→

[ 18 ]

N-(1-Acetyl-1H-benzotriazol-5-yl)-acetamide

反応条件

後処理

1. 1
   その他Excess acetic anhydride and acetic acid were removed in vacuo

実験手順

A solution of 5-amino-1H-benzotriazole (1.07 g, 8 mmol) in acetic anhydride (50 ml, excess) was stirred at 90° C. for two hours, by which time TLC (A) and ninhydrin development indicated conversion of starting materials. Excess acetic anhydride and acetic acid were removed in vacuo to afford [18] as an off white solid. Rf (A) 0.48; m/z (FAB) 219.08632 [(M+H)+ calc. for C10H11N4O2 219.08820].

出典