反応 #46030

反応方程式

sodium hydride

2-fluoro-3-((4-propylcyclohexyl)phenyl)phenol

chloromethyl methyl ether

→

2-fluoro-3-((4-propylcyclohexyl)phenyl)-1-methoxymethoxybenzene

収率 107.6%

溶媒

THF

water

water

water

反応条件

後処理

1. 1
   workup.STIRRINGby stirring at ambient temperature for 4 hours
2. 2
   その他After terminating
3. 3
   その他the reaction
4. 4
   抽出the aqueous layer was extracted with toluene, which
5. 5
   workup.ADDITIONwas added to the organic layer
6. 6
   洗浄the organic layer was washed with a saturated salt solution
7. 7
   乾燥dried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThe solvent was distilled off

実験手順

Under a nitrogen atmosphere, 1.52 g of sodium hydride was added to 9.45 g of 2-fluoro-3-((4-propylcyclohexyl)phenyl)phenol (5) dissolved in 60 mL of THF cooling with iced water, and the mixture was stirred at ambient temperature for 30 minutes. 3.07 g of chloromethyl methyl ether was added to the solution under cooling with iced water, followed by stirring at ambient temperature for 4 hours. After terminating the reaction by pouring water into the reaction solution, the aqueous layer was extracted with toluene, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 11.6 g of 2-fluoro-3-((4-propylcyclohexyl)phenyl)-1-methoxymethoxybenzene (6).

出典