反応 #46029

反応方程式

hydrochloric acid

propanoyl chloride

3-((4-propylcyclohexyl)cyclohexyl)phenol

water

→

3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate

収率 109.9%

溶媒

pyridine

反応条件

後処理

1. 1
   workup.ADDITIONaddition
2. 2
   抽出The aqueous layer was extracted with diethyl ether, which
3. 3
   workup.ADDITIONwas added to the organic layer
4. 4
   洗浄the organic layer was washed with a saturated salt solution
5. 5
   乾燥dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off

実験手順

Under a nitrogen atmosphere, 1.7 g of propanoyl chloride was added to 5.0 g of 3-((4-propylcyclohexyl)cyclohexyl)phenol (3) dissolved in 10 mL of pyridine under cooling with iced water, and after completing dropwise addition, the mixture was stirred at ambient temperature for 2 hours. The resulting solution was added to 20 mL of 3N hydrochloric acid. The aqueous layer was extracted with diethyl ether, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 6.52 g of 3-((4-propylcyclohexyl)cyclohexyl)phenyl propanoate (4).

出典