反応 #46014

反応方程式

EtOAc

4-chloro-3-ethylphenol

1-fluoro-4-nitrobenzene

potassium carbonate

→

4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene

溶媒

DMF

反応条件

後処理

1. 1
   温度After cooling to rt
2. 2
   洗浄washed with H2O (2×50 mL) and brine (50 mL)
3. 3
   乾燥dried over sodium sulfate
4. 4
   その他The solvent was removed in vacuuo

実験手順

To a stirred solution of 1-fluoro-4-nitrobenzene (10 mmol) in DMF (20 mL) at rt, solid potassium carbonate (30 mmol) was added followed by addition of 4-chloro-3-ethylphenol (10 mmol) to the reaction mixture and heating to 80° C. until the reaction was complete as indicated by TLC or HPLC. After cooling to rt, the reaction mixture was poured into EtOAc (100 mL), washed with H2O (2×50 mL) and brine (50 mL), and dried over sodium sulfate. The solvent was removed in vacuuo to afford the desired 4-(4-chloro-3-ethylphenoxy)-1-nitrobenzene. The crude product was used for further transformation.

出典