反応 #459852

反応方程式

sodium

sodium

n-hexadecanol

2,4-dichloro-5-fluoropyrimidine

→

2,4-di(n-hexadecyloxy)-5-fluoropyrimidine

収率 63.1%

溶媒

ether

反応条件

後処理

1. 1
   workup.DISSOLUTIONhas been completely dissolved
2. 2
   温度the mixture is refluxed for 3 hours
3. 3
   その他The resulting reaction mixture
4. 4
   洗浄is washed with a small amount of water
5. 5
   濃縮the ethereal layer is concentrated
6. 6
   その他to separate out crystals, which
7. 7
   その他are recrystallized from ethanol

実験手順

A 36.3 g quantity of n-hexadecanol is dissolved in 200 ml of absolute ether, 3.3 g of metal sodium is added to the solution and the mixture is refluxed until the sodium has been completely dissolved. Subsequently 8.5 g of 2,4-dichloro-5-fluoropyrimidine is added to the solution, and the mixture is refluxed for 3 hours. The resulting reaction mixture is washed with a small amount of water, and the ethereal layer is concentrated to separate out crystals, which are recrystallized from ethanol to give 18.6 g of white crystalline 2,4-di(n-hexadecyloxy)-5-fluoropyrimidine in a yield of 63.1%, m.p. 62°-63° C.

出典