反応 #459691

反応方程式

1-chloro-4-hydroxynonane

dihydropyrane

sodium hydroxide

→

1-Chloro-4-(2-tetrahydropyranyloxy)nonane

反応条件

後処理

1. 1
   その他A slight exothermic reaction
2. 2
   その他to come to room temperature
3. 3
   workup.DISTILLATIONthe reaction is distilled in vacuo
4. 4
   その他boiling 96°-102°
5. 5
   workup.DISTILLATIONUpon redistillation a boiling point of 90°-92°/0.1 mm
6. 6
   その他is obtained

実験手順

To a stirred solution of 1-chloro-4-hydroxynonane (Example A, Step 2) (11.0 g., 0.062 mole) and dihydropyrane (5.2 g., 0.062 mole) cooled in an ice bath is added 5 drops of hydrochloric acid (conc.). A slight exothermic reaction is noted and when this is complete the reaction is allowed to come to room temperature, then stand for 2 hours. At the end of this period several pellets of sodium hydroxide are added and the reaction is distilled in vacuo. The yield of 1-chloro-4-(2-tetrahydropyranyloxy)nonane is 12.5 g. (77%), boiling 96°-102°/0.1 mm. Upon redistillation a boiling point of 90°-92°/0.1 mm. is obtained.

出典