反応 #45930
ord-da35513542f84da8825139e72ef6d024
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他The reaction was quenched by cold H2O (50 mL)
- 2抽出the resulting mixture was extracted with EtOAc (3×100 mL)
- 3洗浄The combined EtOAc extracts were washed with brine (3×50 mL)
- 4乾燥dried (anhydrous Na2SO4)
- 5その他The solvent was removed in vacuo
実験手順
To a stirred solution of 6-(3-diethylaminopropoxy)-2,4-difluoronitrobenzene (11 mmol) and triethylamine (22 mmol) in DMF (20 mL), a solution of n-butylamine (11 mmol) in DMF (8 mL) was added dropwise at rt, and the mixture was stirred at rt for 10 h. The reaction was quenched by cold H2O (50 mL), and the resulting mixture was extracted with EtOAc (3×100 mL). The combined EtOAc extracts were washed with brine (3×50 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-6-(3-diethylaminopropoxy)-4-fluoronitrobenzene which was used for further transformation.