反応 #45926
ord-c062db97d9534d338977671ba9c26a1b
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他The reaction was quenched by cold H2O (100 mL)
- 2抽出the resulting mixture was extracted with EtOAc (4×100 mL)
- 3洗浄The combined EtOAc extracts were washed with brine (3×60 mL)
- 4乾燥dried (anhydrous Na2SO4)
- 5その他The solvent was removed in vacuo
実験手順
To a stirred solution of 2,4-difluoronitrobenzene (50 mmol), Et3N (100 mmol) and DMF (80 mL) was added dropwise a solution of n-butylamine (51 mmol) in DMF (20 mL) at rt, and the mixture was stirred at rt for 5 h. The reaction was quenched by cold H2O (100 mL), and the resulting mixture was extracted with EtOAc (4×100 mL). The combined EtOAc extracts were washed with brine (3×60 mL) and dried (anhydrous Na2SO4). The solvent was removed in vacuo to afford the desired 2-n-butylamino-4-fluoronitrobenzene which was used for further transformation.