反応 #45913

反応方程式

Benzyl (3S)-3-[(tert-butoxycarbonyl)(methyl)amino]-3-methylpyrrolidine-1-carboxylate

→

crude product

tert-Butyl methyl[(3S)-3-methylpyrrolidin-3-yl]carbamate

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他The reaction liquid
2. 2
   ろ過was filtered
3. 3
   濃縮the filtrate was concentrated under reduced pressure

実験手順

Benzyl (3S)-3-[(tert-butoxycarbonyl)(methyl)amino]-3-methylpyrrolidine-1-carboxylate (I-347) (367 mg, 1.05 mmol) was dissolved in 1,4-dioxane (10 ml), then palladium hydroxide catalyst (37 mg) was added, followed by stirring under hydrogen atmosphere at room temperature for 5 hours. The reaction liquid was filtered, and the filtrate was concentrated under reduced pressure to obtain a crude product of the entitled compound. This was used in the next reaction as such.

出典