反応 #4584

反応方程式

2-(2-propanon-1-yloxy)phenylsulfonamide

ethylene glycol

p-toluenesulfonic acid

toluene

→

2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide

溶媒

ethyl acetate

反応条件

後処理

1. 1
   温度is heated for 7 hours
2. 2
   温度to reflux
3. 3
   その他while simultaneously separating
4. 4
   その他the water of reaction
5. 5
   洗浄the organic phase is washed with saturated sodium bicarbonate solution and water
6. 6
   その他dried
7. 7
   濃縮concentrated

実験手順

A mixture of 4.58 g of 2-(2-propanon-1-yloxy)phenylsulfonamide, 2 ml of ethylene glycol, 0.02 g of p-toluenesulfonic acid and 30 ml of toluene is heated for 7 hours to reflux while simultaneously separating the water of reaction. The cooled solution is taken up in 80 ml of ethyl acetate and the organic phase is washed with saturated sodium bicarbonate solution and water, dried and concentrated, affording 5 g of 2-(2-methyl-1,3-dioxolan-2-yl-methoxy)phenylsulfonamide in the form of a yellow viscous oil which can be further used without purification.

出典