反応 #4583

反応方程式

3-chloroperbenzoic acid

2-allyloxyphenylsulfonamide

→

2-oxiranylmethoxyphenylsulfonamide

収率 78.0%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度The solution is then heated
2. 2
   温度to reflux for 3 hours
3. 3
   温度cooled
4. 4
   洗浄washed three times with saturated sodium carbonate solution
5. 5
   その他The organic phase is dried
6. 6
   濃縮concentrated

実験手順

To a mixture of 15.3 g of 3-chloroperbenzoic acid in 270 ml of absolute methylene chloride are added 14.2 g of 2-allyloxyphenylsulfonamide over 2 minutes. The solution is then heated to reflux for 3 hours, cooled, and then washed three times with saturated sodium carbonate solution and once with water. The organic phase is dried and concentrated, affording 11.9 g of 2-oxiranylmethoxyphenylsulfonamide with a melting point of 132°-133° C.

出典