反応 #45829

反応方程式

potassium nitrate

6-amino-3-bromo-4-fluoro-2-methylbenzonitrile

→

2-Amino-5-bromo-4-fluoro-6-methyl-3-nitrobenzonitrile

溶媒

sulfuric acid

反応条件

後処理

1. 1
   その他the reaction liquid
2. 2
   workup.ADDITIONwas poured into ice
3. 3
   workup.STIRRINGstirred

実験手順

With cooling with ice, potassium nitrate (2.43 g, 21.8 mmol) was gradually added to a concentrated sulfuric acid (20 ml) solution of 6-amino-3-bromo-4-fluoro-2-methylbenzonitrile (I-265) (5.00 g, 21.8 mmol). After stirring for 10 minutes, the reaction liquid was poured into ice and stirred.

出典