反応 #4582

反応方程式

phosgene

2-(1-methoxycarbonylethoxy)-benzenesulfonamide

n-butylisocyanate

phosgene

→

2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate

収率 125.5%

溶媒

xylene

反応条件

後処理

1. 1
   温度is refluxed for 30 minutes
2. 2
   温度the solution is then cooled
3. 3
   濃縮concentrated in vacuo

実験手順

A mixture of 12.9 g of 2-(1-methoxycarbonylethoxy)-benzenesulfonamide, 4.9 g of n-butylisocyanate and 0.1 g of diazabicyclooctane and 130 ml of xylene is refluxed for 30 minutes. Then 10 g of phosgene are passed into the solution at the same temperature over 90 minutes. Excess phosgene is expelled with nitrogen and the solution is then cooled and concentrated in vacuo, affording 17.7 g of 2-(1-methoxycarbonylethoxy)benzenesulfonyl isocyanate in the form of a brownish oil which can be further used without purification.

出典