反応 #4577

反応方程式

methyl 5-chlorooxindole-3-carboxylate

phenylisocyanate

→

Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

溶媒

toluene

—

petroleum ether

反応条件

後処理

1. 1
   温度heated
2. 2
   温度to reflux overnight
3. 3
   温度The reaction mixture was cooled
4. 4
   その他to give
5. 5
   ろ過after filtration
6. 6
   その他drying

実験手順

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

出典