反応 #456839

反応方程式

3,5-diethyl-4-(4-(3,3-dichloro-2-propenyloxy)butyloxy)phenol

1,1,3-trichloro-1-propene

potassium carbonate

N,N-dimethylformamide

→

3,5-diethyl-1-(3,3-dichloro-2-propenyloxy)-4-(4-(3,3-dichloro-2-propenyloxy)butyloxy)benzene

収率 72.0%

溶媒

water

反応条件

後処理

1. 1
   抽出extracted twice with 50 ml of diethyl ether
2. 2
   洗浄washed with water
3. 3
   乾燥dried over magnesium sulfate
4. 4
   濃縮concentrated

実験手順

A reaction vessel was charged with 0.35 g of 3,5-diethyl-4-(4-(3,3-dichloro-2-propenyloxy)butyloxy)phenol, 0.16 g of 1,1,3-trichloro-1-propene, 0.15 g of potassium carbonate and 10 ml of N,N-dimethylformamide. After stirring at room temperature for 24 hours, the reaction mixture was poured into water and extracted twice with 50 ml of diethyl ether. The diethyl ether layers were combined, washed with water, dried over magnesium sulfate and then concentrated. The residue was subjected to silica gel chromatography, which afforded 0.33 g of 3,5-diethyl-1-(3,3-dichloro-2-propenyloxy)-4-(4-(3,3-dichloro-2-propenyloxy)butyloxy)benzene (yield, 72%), nD24.4 1.5311.

出典