反応 #45579

反応方程式

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

溶媒

brine

反応条件

後処理

1. 1
   抽出followed by extraction twice with ethyl acetate
2. 2
   洗浄the organic layer was washed three times with saturated brine
3. 3
   乾燥dried over anhydrous magnesium sulfate

実験手順

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

出典