反応 #4553

反応方程式

water

4-(4-bromo-2-fluorophenoxy)phenol

methyl 2-bromoproprionate

potassium carbonate

→

2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionic acid

4-(4-bromo-2-fluorophenoxy)phenoxy propionic acid methyl ester

溶媒

DMSO

反応条件

後処理

1. 1
   抽出the resulting mixture extracted with ether (2×100 ml)
2. 2
   洗浄washed with water (100 ml)
3. 3
   乾燥dried (MgSO4)
4. 4
   その他the solvent evaporated

実験手順

A mixture of the 4-(4-bromo-2-fluorophenoxy)phenol (5.66 g, 0.02 mol) from Step V, methyl 2-bromoproprionate (3.34 g, 0.02 mol) and potassium carbonate (3.06 g, 0.22 mol) in DMSO (30 ml) was stirred, under an atmosphere of nitrogen, at room temperature for 18 hours. The mixture was poured into water (300 ml), and the resulting mixture extracted with ether (2×100 ml). The ether extracts were combined, washed with water (100 ml), dried (MgSO4), and the solvent evaporated to give the desired 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionic acid; methyl ester as a yellow oil (6.0 g, 81%); RI=1.5628; NMR (CDCl3) was consistent with the assigned structure. The carbon and hydrogen content was as follows:

出典