反応 #4547

反応方程式

active amyl alcohol

potassium carbonate

4-cyanophenol

brom-6-methyl octane

→

(s)-4-(6-methyloctyloxy)benzonitrile

溶媒

N,N-dimethyl formamide

反応条件

後処理

1. 1
   その他to react for 8 hours at 110° C
2. 2
   その他After the reaction
3. 3
   ろ過filter the insoluble matter
4. 4
   洗浄The organic layer is then washed with 5% NaOH, water and saturated salt water
5. 5
   その他dried
6. 6
   その他evaporated
7. 7
   その他to remove the ether

実験手順

Add 5.75 g of 4-cyanophenol 10 g of 1 brom-6-methyl octane synthesized of available active amyl alcohol, 6.67 g of anhydrous potassium carbonate, 30 ml of N,N-dimethyl formamide into 100 ml four-mouth flask under nitrogen atmosphere, allow to react for 8 hours at 110° C. After the reaction, filter the insoluble matter, then extract ether. The organic layer is then washed with 5% NaOH, water and saturated salt water, then dried and evaporated to remove the ether. Then when the obtained oily matter is refined, 11.4 g of optical (s)-4-(6-methyloctyloxy)benzonitrile is obtained.

出典