反応 #45429

反応方程式

solution

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

→

desired product

収率 89.0%

4-amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

収率 89.0%

溶媒

THF

反応条件

後処理

1. 1
   ろ過filtered through diatomaceous earth (Celite®)
2. 2
   洗浄The pad was washed with THF and dichloromethane
3. 3
   濃縮the combined filtrates were concentrated

実験手順

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

出典