反応 #4542

反応方程式

3

2-Amino-6-chloro-3,5-pyridinedicarbonitrile

→

2-Amino-3,5-dicyanopyridine

収率 73.0%

溶媒

cyclohexane EtOAc

反応条件

後処理

1. 1
   その他described below for the preparation of 5 except that 5
2. 2
   その他was recrystallised from MeCN [methyl cyanide

実験手順

2-Amino-3,5-dicyanopyridine (5) was prepared from 3 using the procedure described below for the preparation of 5 except that 5 was recrystallised from MeCN [methyl cyanide; acetonitrile) (instead of EtOH). The yield was 73% (7.00 g from 12.0 g (67.2 mmol) of 3] of product homogeneous on TLC (cyclohexane-EtOAc, 1:1); mp 220° C. dec; 1H NMR (Me2SO-d6) δ7.90 (s, NH2), 8.40 and 8.58 (two d, 4-H and 6H, J=2 Hz).

出典