反応 #4538

反応方程式

3-formyl-5-dichloromethyl-2-phthalimidopyrazine

hydroxylamine hydrochloride

water

→

colorless crystals

収率 67.4%

3-oximino-5-dichloromethyl-2-phthalimidopyrazine

収率 67.4%

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   ろ過the mixture was filtered
2. 2
   洗浄the filtrate was washed with a little diethyl ether

実験手順

A solution of 10 g of 3-formyl-5-dichloromethyl-2-phthalimidopyrazine in 50 ml of dimethyl sulfoxide was heated at 50° C., 7 g of hydroxylamine hydrochloride were added, and the mixture was stirred for 15 minutes at 70° C. Thereafter, 700 ml of water were added to the reaction solution, the mixture was filtered and the filtrate was washed with a little diethyl ether. 6.8 g of colorless crystals (65%) of 3-oximinodichloromethyl-2-phthalimidopyrazine were obtained. 1H-NMR (270 MHz, DMSO-d6): δ7.7 (s, 1H), 8.0 (m, 4H), 8.3 (s, 1HO), 9.1 (s, 1H), 12.0 (s, OH).

出典