反応 #45281

反応方程式

Tributyltin hydride

Z-dehydro-Ala-OH

1-methylcyclopentanyl-bromide

AIBN

→

2-benzyloxycarbonylamino-3-(1-methyl-cyclopentyl)-propionic acid methyl ester

収率 38.6%

溶媒

benzene

反応条件

後処理

1. 1
   温度at reflux to a 500 mL of flask
2. 2
   その他the solvent was removed
3. 3
   その他the residue was purified by column chromatograph

実験手順

Tributyltin hydride (37.8 g, 130 mmol) was added at reflux to a 500 mL of flask charged with benzene (200 mL) was added Z-dehydro-Ala-OH (15 g, 64 mmol), 1-methylcyclopentanyl-bromide (20.5 g) and AIBN (1.9 g). After 2 h, the solvent was removed and the residue was purified by column chromatograph to yield 2-benzyloxycarbonylamino-3-(1-methyl-cyclopentyl)-propionic acid methyl ester (7.9 g).

出典