反応 #45261

反応方程式

solution

1-[2-(4-hydroxymethyl-phenyl)-5-isopropyl-2H-pyrazol-3-yl]-3-naphthalen-1-yl-urea

CH2Cl2

→

1-[5-t-butyl-2-(4-formyl-phenyl)-2H-pyrazol-3-yl]-3-naphthalen-1-yl-urea

反応条件

後処理

1. 1
   ろ過then filtered through celite
2. 2
   濃縮The filtrate was concentrated under reduced pressure

実験手順

To a solution of Example 204 (200 mg) in CH2Cl2 (50 mL) was added MnO2 (450 mg) at RT. The suspension was stirred for 2 h then filtered through celite. The filtrate was concentrated under reduced pressure to afford 150 mg of 1-[5-t-butyl-2-(4-formyl-phenyl)-2H-pyrazol-3-yl]-3-naphthalen-1-yl-urea, which was used without further purification.

出典