反応 #452447

反応方程式

Potassium carbonate

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate

benzyl chloride

→

desired compound

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-2-benzylbutyrate

溶媒

acetone

反応条件

後処理

1. 1
   その他fitted with a magnetic stirrer, condenser and argon inlet
2. 2
   温度The mixture is heated
3. 3
   温度to reflux for 18 h
4. 4
   ろ過The cooled mixture is filtered
5. 5
   濃縮concentrated by rotary evaporation
6. 6
   その他The resulting oil is purified on silica gel

実験手順

Potassium carbonate (3.92 g, 0.028 mol), 3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate (4.80 g, 0.030 mol), benzyl chloride (4.80 g, 0.038 mol) and acetone (15 mL) are placed in a 50 mL round-bottomed flask fitted with a magnetic stirrer, condenser and argon inlet. The mixture is heated to reflux for 18 h. The cooled mixture is filtered and concentrated by rotary evaporation. The resulting oil is purified on silica gel to yield the desired compound. Structure is confirmed by thin layer chromatography and 1H and 13C NMR.

出典