反応 #452427

反応方程式

ethyl isocyanate

3-(1-pyrrolidinyl)propylamine

→

urea

収率 96.4%

N-ethyl-N'-3-(1-pyrrolidinyl)propylurea

収率 96.4%

溶媒

chloroform

反応条件

後処理

1. 1
   温度with cooling
2. 2
   workup.ADDITIONOnce the addition
3. 3
   その他the cooling bath was removed
4. 4
   濃縮The reaction mixture was then concentrated under reduced pressure

実験手順

To a solution of 27.7 gm (0.39 mole) ethyl isocyanate in 250 mL chloroform were added 50 gm (0.39 mole) 3-(1-pyrrolidinyl)propylamine dropwise with cooling. Once the addition was complete, the cooling bath was removed and the reaction mixture stirred at room temperature for 4 hours. The reaction mixture was then concentrated under reduced pressure to give 74.5 gm (96.4%) of the desired urea as a clear oil.

出典