反応 #452426

反応方程式

2-iodopropane

2-(4-pyrazolyl)-1-ethanol

sodium carbonate

→

title compound

収率 26.0%

2-(1-isopropyl-1H-pyrazol-4-yl)-1-ethanol

収率 26.0%

溶媒

dimethylformamide

dimethylformamide

反応条件

後処理

1. 1
   温度The reaction mixture was then cooled to ambient and
2. 2
   濃縮then concentrated under reduced pressure
3. 3
   その他The residue was partitioned between water and dichloromethane
4. 4
   洗浄The organic phase was then washed with water
5. 5
   乾燥was then dried over sodium sulfate
6. 6
   濃縮The remaining organics were concentrated under reduced pressure

実験手順

To a solution of 1.0 gm (9.0 mMol) 2-(4-pyrazolyl)-1-ethanol in 36 mL dimethylformamide were added 2.38 gm (22.5 mMol) sodium carbonate followed by the dropwise addition of a solution of 0.89 mL (9.0 mMol) 2-iodopropane in 8 mL dimethylformamide. The reaction mixture was heated to 100° C. for 18 hours. The reaction mixture was then cooled to ambient and then concentrated under reduced pressure. The residue was partitioned between water and dichloromethane. The organic phase was then washed with water followed by saturated aqueous sodium chloride and was then dried over sodium sulfate. The remaining organics were concentrated under reduced pressure to give 0.36 gm (26.0%) of the title compound as a brown oil.

出典