反応 #452423

反応方程式

water

4-fluorobenzoyl chloride

4-nitroaniline

pyridine

→

N-(4-fluorobenzoyl)-4-nitroaniline

収率 91.3%

溶媒

dichloromethane

反応条件

後処理

1. 1
   workup.WAITfor an hour at room temperature
2. 2
   その他the solid which formed
3. 3
   ろ過was collected by filtration
4. 4
   洗浄The filter cake was washed with hexane (80 mL)
5. 5
   その他was then dried under vacuum at 60° C.

実験手順

To a stirred suspension of 19.83 gm (143.56 mMol) 4-nitroaniline in 150 mL dichloromethane and 12.9 mL (159.5 mMol) pyridine at 0° C. were slowly added 24.5 gm (154.8 mMol) 4-fluorobenzoyl chloride. The reaction mixture was then stirred for 15 minutes at 0° C., at which time the reaction mixture became homogeneous, and then for an hour at room temperature. To this mixture were then added 100 mL water and the solid which formed was collected by filtration. The filter cake was washed with hexane (80 mL) followed by water (100 mL) and it was then dried under vacuum at 60° C. to give 34.1 gm (91%) N-(4-fluorobenzoyl)-4-nitroaniline.

出典