反応 #452415

反応方程式

3-(n-butylamino)phenol

2-bromoethanol

NaHCO3

→

3-[N-(n-butyl)-N-(2-hydroxyethyl)amino]phenol

収率 54.0%

溶媒

methanol

反応条件

後処理

1. 1
   温度After cooling
2. 2
   ろ過the mixture is filtered
3. 3
   その他the solvent is removed in vacuo

実験手順

0.1 mol of 3-(n-butylamino)phenol in 100 ml of methanol is refluxed for 10 h with 0.11 mol of 2-bromoethanol and 0.1 mol of NaHCO3. After cooling, the mixture is filtered, the solvent is removed in vacuo, and the residue is fractionated, to give 3-[N-(n-butyl)-N-(2-hydroxyethyl)amino]phenol.

出典