反応 #4523

反応方程式

tert-butyl 1,2,2,2-tetrachloroethyl carbonate

imidazole

potassium carbonate

→

tert-butyloxycarbonylimidazole

溶媒

THF

THF

反応条件

後処理

1. 1
   その他the organic phase is decanted
2. 2
   洗浄washed with 10 ml of saturated aqueous NaCl solution

実験手順

5 g (17.5 mmol) of tert-butyl 1,2,2,2-tetrachloroethyl carbonate dissolved in 10 ml of THF are added at 0° C. to a solution of imidazole (1.2 g; 17.6 mmol) in THF (20 ml) in the presence of 5M aqueous potassium carbonate solution (5 ml). The mixture is stirred for 1 hour at 20° C., and the organic phase is decanted and washed with 10 ml of saturated aqueous NaCl solution.

出典