反応 #451726

反応方程式

2-(2-Formamidothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid

N,N-dimethylformamide

phosphoryl chloride

4-nitrobenzyl 7-amino-3-cephem-4-carboxylate

→

4-nitrobenzyl 7-[2-(2-formamidothiazol-4-yl)-2-cyclohexyloxyiminoacetamido]-3-cephem-4-carboxylate

収率 90.8%

溶媒

water

acetone

tetrahydrofuran

反応条件

実験手順

2-(2-Formamidothiazol-4-yl)-2-cyclohexyloxyiminoacetic acid (syn isomer, 0.9 g.), N,N-dimethylformamide (266 mg.), phosphoryl chloride (557 mg.), tetrahydrofuran (20 ml.), 4-nitrobenzyl 7-amino-3-cephem-4-carboxylate (1.05 g.), acetone (3 ml.) and water (3 ml.) were treated in a similar manner to that of Example 15-(1) to give 4-nitrobenzyl 7-[2-(2-formamidothiazol-4-yl)-2-cyclohexyloxyiminoacetamido]-3-cephem-4-carboxylate (syn isomer, 1.69 g.).

出典