反応 #451723

反応方程式

2-(2-Formamidothiazol-4-yl)-2-iso-butoxyiminoacetic acid

N,N-dimethylformamide

phosphoryl chloride

4-nitrobenzyl 7-amino-3-cephem-4-carboxylate

→

4-nitrobenzyl 7-[2-(2-formamidothiazol-4-yl)-2-iso-butoxyiminoacetamido]-3-cephem-4-carboxylate

収率 91.0%

溶媒

water

acetone

tetrahydrofuran

反応条件

実験手順

2-(2-Formamidothiazol-4-yl)-2-iso-butoxyiminoacetic acid (syn isomer, 6.48 g.), N,N-dimethylformamide (2.10 g.), phosphoryl chloride (4.40 g.), tetrahydrofuran (110 ml.), 4-nitrobenzyl 7-amino-3-cephem-4-carboxylate (8.23 g.), acetone (16 ml.) and water (16 ml.) were treated in a similar manner to that of Example 15-(1) to give 4-nitrobenzyl 7-[2-(2-formamidothiazol-4-yl)-2-iso-butoxyiminoacetamido]-3-cephem-4-carboxylate (syn isomer, 12.8 g.).

出典