反応 #4506

反応方程式

4-chloromethyl-5-methyl-2-phenyloxazole

4-hydroxybenzaldehyde

potassium carbonate

→

4-(5-methyl-2-phenyl-4-oxazolyl)methoxybenzaldehyde

収率 100.1%

反応条件

後処理

1. 1
   workup.ADDITIONThe reaction solution was poured into ice-cold water
2. 2
   その他the crystals which separated out
3. 3
   ろ過were collected by filtration

実験手順

A mixture of 4-chloromethyl-5-methyl-2-phenyloxazole (3.12 g), 4-hydroxybenzaldehyde (1.83 g), potassium carbonate (2.28 g) and dimethylformaide (40 ml) was stirred under heating at 110° C. for 1 hour. The reaction solution was poured into ice-cold water, and the crystals which separated out were collected by filtration to give 4-(5-methyl-2-phenyl-4-oxazolyl)methoxybenzaldehyde (4.40 g, 99.8%). Recrystallization from ether-hexane yielded colorless prisms, m.p. 112°-113° C. Elemental analysis for C18H15NO3 ; Calcd.: C, 73.71; H, 5.15; N, 4.87. Found: C, 73.87; H, 5.26; N, 4.81.

出典