反応 #449705

ord-1c44a6bdbf0e4c258f639372041fa810

反応方程式

CC(C)(C)OC(=O)N1CCC(Oc2ccc(NCc3ccc4ccc(C#N)cc4c3)cc2)CC1
7-[[4-[(1-t-butoxycarbonyl-4-piperidyl)oxy]anilino]methyl]-2-naphthalenecarbonitrile
O=S(=O)(Cl)Cc1ccccc1
benzylsulfonyl chloride
→
CC(C)(C)OC(=O)N1CCC(Oc2ccc(N(Cc3ccc4ccc(C#N)cc4c3)S(=O)(=O)Cc3ccccc3)cc2)CC1
N-[4-[(1-t-Butoxycarbonyl-4-piperidyl)oxy]phenyl]-N-[(7-cyano-2-naphthyl)methyl]benzylsulfonamide

反応物

CC(C)(C)OC(=O)N1CCC(Oc2ccc(NCc3ccc4ccc(C#N)cc4c3)cc2)CC1
7-[[4-[(1-t-butoxycarbonyl-4-piperidyl)oxy]anilino]methyl]-2-naphthalenecarbonitrile
O=S(=O)(Cl)Cc1ccccc1
benzylsulfonyl chloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Starting compound: 7-[[4-[(1-t-butoxycarbonyl-4-piperidyl)oxy]anilino]methyl]-2-naphthalenecarbonitrile, benzylsulfonyl chloride.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05869501uspto-grants-1999_02