反応 #44954

反応方程式

Pseudomonic acid

potassium hydroxide

calcium chloride

→

Mupirocin Calcium

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過the solution was filtered
2. 2
   その他to remove potassium chloride (0.51 g)
3. 3
   その他The ethanol was subsequently evaporated at reduced pressure
4. 4
   その他to give a solid, white foam
5. 5
   その他The product was dried for 12 hours at 45° C. under vacuum

実験手順

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in ethanol (20 ml), ethanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 10 ml ethanol) and ethanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 10 ml ethanol) were added to the mixture. The mixture was stirred for 1 hour and the solution was filtered to remove potassium chloride (0.51 g). The ethanol was subsequently evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum. The product had a mass of 4.38 grams. Assay: 99.1%, water: 2.36% [total impurity: 2.44%, highest impurity: 1.10% different method than the assay].

出典