反応 #44951

反応方程式

Pseudomonic acid

Calcium 2-ethyl-hexanoate

pseudomonic acid

calcium 2-ethyl-hexanoate

→

Mupirocin Calcium Dihydrate

溶媒

water

water

isobutyl methyl ketone

反応条件

後処理

1. 1
   その他to obtain a solution
2. 2
   その他The two phases were then separated
3. 3
   workup.ADDITIONisobutyl methyl ketone (25 ml) was added to the aqueous phase
4. 4
   workup.STIRRINGstirred for 10 minutes
5. 5
   その他The two resulting phases were separated
6. 6
   その他any traces of isobutyl methyl ketone was evaporated from the aqueous phase
7. 7
   ろ過The solid mupirocin calcium dihydrate was filtered
8. 8
   洗浄washed with water (20 ml)
9. 9
   その他dried under vacuum at 35° C. for 14 hours

実験手順

Pseudomonic acid (10.00 g, 20 mmole) was dissolved in isobutyl methyl ketone (100 ml) at 40° C. Calcium-2-ethyl-hexanoate (3.32 g, 10 mmole) was suspended in water (50 ml). (It is possible to obtain a solution by using a larger amount of water or an alcohol/water mixture). The solution of pseudomonic acid was added to the calcium-2-ethyl-hexanoate suspension, and the two phase system were stirred for 24 hours. The two phases were then separated, isobutyl methyl ketone (25 ml) was added to the aqueous phase, and stirred for 10 minutes. The two resulting phases were separated, and any traces of isobutyl methyl ketone was evaporated from the aqueous phase. The aqueous mupirocin calcium suspension was cooled in a refrigerator at 5° C. The solid mupirocin calcium dihydrate was filtered, washed with water (20 ml) and dried under vacuum at 35° C. for 14 hours. The mass of product was 7.95 grams. Assay 97.72%, water: 3.45%.

出典