反応 #44841

反応方程式

2-chlorobenzimidazole

7-fluoro-1,2,3,4-tetrahydro-1-naphthylamine

→

title compound

N-(Benzimidazol-2-yl)-7-fluoro-1,2,3,4-tetrahydro-1-naphthylamine

反応条件

後処理

1. 1
   その他The product was purified by column chromatography

実験手順

The title compound was prepared from 2-chlorobenzimidazole and 7-fluoro-1,2,3,4-tetrahydro-1-naphthylamine (prepared by Procedure B from 7-fluoro-1 -tetralone) by Procedure A. The product was purified by column chromatography to give the title compound as the free base and as a mixture of enantiomers (white solid, mp 181° C.). MS(ES+) m/z 282 ([M+1]+, 100).

出典