反応 #4476

反応方程式

water

potassium carbonate

product

1,2,3,9-Tetrahydro-6-methoxy-4H-carbazol-4-one

Dimethyl sulphate

→

title compound

収率 78.2%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

収率 78.2%

溶媒

acetone

反応条件

後処理

1. 1
   温度the mixture was heated
2. 2
   温度to reflux for 4 h
3. 3
   ろ過the resulting precipitate filtered off

実験手順

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

出典