反応 #44753

反応方程式

4-bromophenol

4-fluorobenzaldehyde

potassium carbonate

→

4-(4-bromophenoxy)benzaldehyde

溶媒

DMF

反応条件

後処理

1. 1
   温度After cooling to ambient temperature

実験手順

The mixture of 4-bromophenol (10 g, 57.8 mmol), 4-fluorobenzaldehyde (7.17 g, 57.9 mmol), and potassium carbonate (12 g, 86.7 mmol) in DMF was heated at 170° C. for 4 hours. After cooling to ambient temperature, the reaction mixture was poured into ice-water. The resulting solid, 4-(4-bromophenoxy)benzaldehyde, was isolated by filtration (15 g, 94%), 1H NMR (CDCl3) δ 9.95 (s, 1H), 7.85 (d, 2H), 6.62 (d, 2H), 7.17 (d, 2H), 6.96 (d, 2H) ppm.

出典