反応 #447147

反応方程式

4,5-difluorophthalic acid

n-tridecane

→

3,4-difluorobenzoic acid

収率 87.0%

溶媒

N-methyl-2-pyrrolidone

反応条件

後処理

1. 1
   その他consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield

実験手順

4,5-difluorophthalic acid (0.55 grams, 2.7 mmole) was added to a slurry of cupric oxide (10% by weight of starting material) in 5 ml. of N-methyl-2-pyrrolidone solvent. n-tridecane (0.25 grams) was added as an internal standard. The mixture was heated to 190° C. for 3 hours, at which time GC analysis indicated complete consumption of the starting material and conversion to 3,4-difluorobenzoic acid in an 87% yield, based upon the internal standard, corrected for response factors.

出典