反応 #4470

反応方程式

cyclohexane-1,3-dione

4-fluorophenylhydrazine hydrochloride

sodium hydroxide

→

title compound

収率 96.4%

3-Hydroxy-2-cyclohexen-1-one (4-fluorophenyl)hydrazone

収率 96.4%

溶媒

water

water

water

反応条件

後処理

1. 1
   ろ過the precipitate was filtered off
2. 2
   洗浄washed with water (50 ml), air
3. 3
   その他dried for 1 h
4. 4
   乾燥dried in vacuo over phosphorus pentoxide at 75°

実験手順

A suspension of 4-fluorophenylhydrazine hydrochloride (50 g) in water (500 ml) was treated with sodium hydroxide (12.3 g) in water (50 ml) and the resultant solution added to solution of cyclohexane-1,3-dione (97%, 35.6 g) in water (300 ml) over 2 h under nitrogen with stirring. After a further 30 min, the precipitate was filtered off, washed with water (50 ml), air dried for 1 h, and dried in vacuo over phosphorus pentoxide at 75° to give the title compound as a powder (65.3 g) m.p. 175°-176°.

出典