反応 #44694

反応方程式

4-nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide

hexamethyldisilazane

methyl chloroformate

→

6-Chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine

溶媒

THF

反応条件

後処理

1. 1
   ろ過The reaction solution is filtered through a silica gel cartridge
2. 2
   洗浄is then washed with DCM/methanol 10:1

実験手順

Under an atmosphere of argon, 5.00 g (27.9 mmol) of 4-nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide (from example XVI) and 11.8 ml (55.8 mmol) of hexamethyldisilazane are initially charged in 290 ml of THF. At room temperature, 10.8 ml (139.6 mmol) of methyl chloroformate are added. The solution is stirred at RT overnight. The reaction solution is filtered through a silica gel cartridge, and is then washed with DCM/methanol 10:1.

出典