反応 #44660

反応方程式

(R)-5-(3,4,5-trifluorophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester

→

titled compound

収率 95.9%

(2R,5S)-5-(3,4,5-trifluorophenyl)-pyrrolidine-2-carboxylic acid ethyl ester

収率 95.9%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The catalyst was filtered off over Celite
2. 2
   濃縮The obtained filtrate was concentrated

実験手順

To a solution of (R)-5-(3,4,5-trifluorophenyl)-3,4-dihydro-2H-pyrrole-2-carboxylic acid ethyl ester (12.4 g) in ethanol (170 mL) was added 10% palladium-carbon (1.2 g, 50% water content). Under a hydrogen atmosphere, the reaction mixture was stirred for 16 hours at room temperature. The catalyst was filtered off over Celite. The obtained filtrate was concentrated, to thereby obtain the titled compound (11.98 g). The physical properties of the compound were as follows.

出典