反応 #44636

反応方程式

Trifluoroacetic acid

methylene chloride

[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

sodium hydrogencarbonate

→

title compound

収率 91.1%

(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propylamine

収率 91.1%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他The resulting reaction solution
2. 2
   その他The organic layer was separated
3. 3
   洗浄washed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order
4. 4
   濃縮concentrated under reduced pressure

実験手順

Trifluoroacetic acid (0.5 mL) was added to a methylene chloride solution (2 mL) of [(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester (370 mg). The resulting reaction solution was stirred at room temperature for 11 hr, and a saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added thereto. The organic layer was separated, washed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order, and concentrated under reduced pressure to give 275 mg of the title compound. The physical property values of this compound were as follows:

出典