反応 #44595

反応方程式

2-(3,4,5-trimethoxyphenylamino)-6-(4-aminophenyloxy)-pyrazine

4-chlorophenylcarbonyl chloride

→

title compound

収率 34.0%

2-(3,4,5-Trimethoxyphenylamino)-6-[4-(4-chlorophenylcarbonyl)-aminophenyl]-pyrazine

収率 34.0%

溶媒

AcOEt

反応条件

実験手順

Using Method LL with 2-(3,4,5-trimethoxyphenylamino)-6-(4-aminophenyloxy)-pyrazine (50 mg, 0.14 mmol) and 4-chlorophenylcarbonyl chloride (22 μL, 0.17 mmol), and purification by column chromatography (AcOEt), the title compound was obtained (23 mg). Yield: 34%. 1H NMR (250 MHz, DMSO-d6) δ 3.65 (s, 3H, [CH3O]4), 3.85 (s, 6H, [CH3O]3+5), 7.28 (s, 2H, Harom2′+6′), 7.64 (d, 2H, Harom 3+5, J=8.5 Hz), 7.93 (d, 2H, Harom 3″+5″, J=8.6 Hz), 7.93 (m, 2H, Harom 2″+6″), 8.03 (m, 2H, Harom 2+6), 8.14 (s, 1H, HPz 5), 8.53 (s, 1H, HPz 3), 9.56 (s, 1H, NH), 10.50 (s, 1H, NHamide). m/z 491.1 [(M+H)+ calcd for C26H23ClN4O4 490.1].

出典