反応 #445666

反応方程式

6-(α-chloroacetyl)carbostyril

→

6-(α-pyridiniumacetyl)carbostyril chloride

carbostyril

溶媒

pyridine

反応条件

後処理

1. 1
   workup.STIRRINGthe suspension was stirred under ice-
2. 2
   温度cooling for 1 hour
3. 3
   その他The crystals thus precipitated
4. 4
   ろ過were collected by filtration
5. 5
   その他recrystallized from methanol

実験手順

60 Grams of 6-(α-chloroacetyl)carbostyril was suspended in 0.5 kg of pyridine and stirred at 80°-90° C. for 2 hours, then the suspension was stirred under ice-cooling for 1 hour. The crystals thus precipitated were collected by filtration and recrystallized from methanol to obtain 70 g of 6-(α-pyridiniumacetyl)carbostyril chloride 1/2-hydrate in the form of colorless needle-like crystals. Melting point: over 300° C.

出典