反応 #445620

反応方程式

3-[(4-chlorophenyl)thio]-azacycloheptan-2-one

methyl isocyanate

dibutyl-tin dilaurate

→

1-(methylcarbamoyl)-3-[(4-chlorophenyl)thio]-azacycloheptan-2-one

溶媒

toluene

反応条件

後処理

1. 1
   温度under reflux for 5 hours
2. 2
   温度After the mixture has cooled

実験手順

25.6 g (0.1 mol) of 3-[(4-chlorophenyl)thio]-azacycloheptan-2-one together with 5.7 g (0.1 mol) of methyl isocyanate and 100 mg of dibutyl-tin dilaurate in 150 ml of absolute toluene are boiled under reflux for 5 hours. After the mixture has cooled, the solvent is stripped off in vacuo, and the oily residue is used for further reactions.

出典