反応 #44559

反応方程式

2,6-dichloropyrazine

2-phenyl-phenol

→

title compound

収率 65.0%

2-Chloro-6-(2-phenyl-phenyl-oxy)-pyrazine

収率 65.0%

溶媒

AcOEt

cyclohexane

反応条件

後処理

1. 1
   その他Method DD (reaction time: 20 hours)

実験手順

Using Method DD (reaction time: 20 hours) with 2,6-dichloropyrazine (200 mg, 1.34 mmol) and 2-phenyl-phenol (268 mg, 1.49 mmol), and purification by column chromatography (AcOEt:cyclohexane, 1:2), the title compound was obtained (238 mg). Yield: 65%. 1H NMR (250 MHz, DMSO-d6) δ 7.31-7.61 (m, 9H, Harom), 8.43 (s, 1H, HPz 5), 8.46 (s, 1H, HPz 3). m/z: 283.1 [(M+H)+, calcd for C16H11ClN2O 282.1].

出典