反応 #445307
ord-3585672f1bf543eabe53683a2d6a9fcf
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
Substantially equimolar amounts of 2,6-dichloroquinoline and the potassium salt of 3-hydroxybenzoic acid are reacted, in an inert organic solvent, e.g., dimethylsulfoxide giving 5-(6-chloro-2-quinolinoxy)benzoic acid which is nitrated, with, for example, potassium nitrate in the presence of concentrated sulfuric acid to give the corresponding 2-nitrobenzoic acid. The 2-nitrobenzoic acid is then reacted with a suitably substituted--halo compound, e.g., 2-chloropropionate, as described hereinabove.