反応 #44508

反応方程式

product

5-Oxo-cyclooctanecarbonitrile

ammonium acetate

sodium cyanoborohydride

→

5-Amino-cyclooctanecarbonitrile

溶媒

methanol

反応条件

後処理

1. 1
   その他The solvent was evaporated
2. 2
   その他the residue was partitioned with dichloromethane and water
3. 3
   洗浄The organic phase was washed with NaHCO3 solution and brine
4. 4
   乾燥dried (Na2SO4)
5. 5
   ろ過filtered
6. 6
   その他evaporated
7. 7
   その他The crude title compound was used in the following step without further purification

実験手順

The product of Example 10B (0.259 g, 1.71 mmol), ammonium acetate (1.32 g, 17.14 mmol), and sodium cyanoborohydride (0.43 g, 6.84 mmol) was stirred in methanol (8 mL) for twelve hours. The solvent was evaporated and the residue was partitioned with dichloromethane and water. The organic phase was washed with NaHCO3 solution and brine, dried (Na2SO4), filtered, and evaporated. The crude title compound was used in the following step without further purification.

出典